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Article

IGF2 inhibits hippocampal over-activated microglia and alleviates depression-like behavior in LPS- treated male mice.

Brain research bulletin - 1 Mar 2023

Guo Dongming, Xu Yang, Liu Zhenghai, Wang Yingge, Xu Xiaofan, Li Cai, Li Suyun, Zhang Jingwen, Xiong Tianqing, Cao WenYu, Liang Jingyan

Abstract excerpt

Over-activated microglia and inflammatory mediators are found in patients with depression, while manipulation of the microglia function might represent a potential therapeutic strategy. Insulin-like growth factor 2 (IGF2) has been implicated in bacterial infections and autoimmune disorders, but the role of IGF2 on the active phenotype of microglia and neuroinflammation has not been well established. IGF2...

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Identifiers

PMID: 36603794
DOI: 10.1016/j.brainresbull.2023.01.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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