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Electroacupuncture reprograms microglia to drive BDNF-dependent hippocampal neurogenesis and antidepressant responses in chronic stress model

2025-09-26

Abstract excerpt

<title>Abstract</title> <p>Background Aberrant microglial activation and impaired adult hippocampal neurogenesis are critically involved in depression pathogenesis. Although electroacupuncture (EA) demonstrates clinical antidepressant efficacy, its mechanisms in modulating microglia and promoting neurogenesis remain unclear. Methods Male C57BL/6J mice were subjected to chronic mild stress (CMS) for 3 weeks, then...

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Literature Corpus work
6d8a61f1-c9c8-514c-9531-b1e97376085a
DOI
10.21203/rs.3.rs-7545312/v1
Open publication

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Electroacupuncture reprograms microglia to drive BDNF-dependent hippocampal neurogenesis and antidepressant responses in chronic stress modelDOI 10.21203/rs.3.rs-7545312/v1
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