Article

Elevated m 6 A RNA Modifications Associate with Immune Dysregulation and Cancer in People with HIV-1

2026-01-13

Abstract excerpt

<title>Abstract</title> <p>(277 words) Background: N 6-methyladenosine (m 6 A) modifications of human immunodeficiency virus type 1 (HIV-1) and cellular RNA contribute to viral immune evasion and regulation of host and viral gene expression. We reported elevated RNA m 6 A levels in peripheral blood mononuclear cells (PBMCs) from HIV-1 viremic individuals compared to those on antiretroviral therapy (ART). RNA m 6...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8d104127-a442-5b14-8494-d7d121bc31ba
DOI: 10.21203/rs.3.rs-8070380/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Elevated m 6 A RNA Modifications Associate with Immune Dysregulation and Cancer in People with HIV-1DOI 10.21203/rs.3.rs-8070380/v1Read

<i>N</i> <sup>6</sup> -methyladenosine modification of HIV-1 RNA evades RIG-I-mediated sensing to suppresses type-I interferon induction in monocytic cellsSemantic proximity Read

HIV-1 envelope proteins up-regulate N6-methyladenosine levels of cellular RNA independently of viral replicationSemantic proximity Read

Multi-Omics Single-Cell Analysis Reveals Key Regulators of HIV-1 Persistence and Aberrant Host Immune Responses in Early InfectionSemantic proximity Read

An HIV-1 Reference EpitranscriptomeSemantic proximity Read

Transcriptomic crosstalk between viral and host factors drives aberrant homeostasis of T-cell proliferation and cell death in HIV-infected immunological non-respondersSemantic proximity Read

RNA epitranscriptomics: Regulation of infection of RNA and DNA viruses by N 6 ‐methyladenosine (m 6 A)Semantic proximity Read

Deciphering DNA Methylation in HIV InfectionSemantic proximity Read

Epitranscriptomic Addition of m5C to HIV-1 Transcripts Regulates Viral Gene ExpressionSemantic proximity Read

Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progressionSemantic proximity Read

Cannabinoids shift the basal ganglia microRNA m <sup>6</sup> A methylation profile towards an anti-inflammatory phenotype in SIV-infected rhesus macaquesSemantic proximity Read

Plasma Virome of HIV-infected Subjects on Suppressive Antiretroviral Therapy Reveals Association of Differentially Abundant Viruses with Distinct T-cell Phenotypes and InflammationSemantic proximity Read

Methylome-wide Analysis of Chronic HIV Infection Reveals Five-Year Increase in Biological Age and Epigenetic Targeting of HLA.Semantic proximity Read