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Article

No evidence for substrate accumulation in Parkinson brains with GBA mutations.

Movement disorders : official journal of the Movement Disorder Society - 1 Jul 2015

Gegg Matthew E, Sweet Lindsay, Wang Bing H, Shihabuddin Lamya S, Sardi Sergio Pablo, Schapira Anthony H V

Abstract excerpt

BACKGROUND: To establish whether Parkinson's disease (PD) brains previously described to have decreased glucocerebrosidase activity exhibit accumulation of the lysosomal enzyme's substrate, glucosylceramide, or other changes in lipid composition. METHODS: Lipidomic analyses and cholesterol measurements were performed on the putamen (n = 5-7) and cerebellum (n = 7-14) of controls, Parkinson's disease brains with...

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Source

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Identifiers

PMID: 26096906
DOI: 10.1002/mds.26278
PMCID: PMC4529481

Genes

GBA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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