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Article

A broadly neutralizing antibody recognizes a unique epitope with a signature motif common across coronaviruses

15 Aug 2025

Abstract excerpt

Cross-reactive antibodies targeting multiple epitopes have been identified in Sarbecoviruses, but the precise molecular mechanism(s) behind the crossreactivity remain poorly understood. Here, we isolate 3D1, a broadly neutralizing antibody (bnAb) derived from a human combinatorial antibody library targeting the conserved HR1 domain. 3D1 uniquely recognizes a β-turn fold comprising a 6-mer peptide (pepDVVNQN/Q)...

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Identifiers

PMID: 40813592
DOI: 10.1038/s41467-025-63101-1

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