Article

Human embryonic stem cells overexpressing dopaminergic transcription factors survive and differentiate in the substantia nigra in vivo

2022-09-28

Abstract excerpt

<title>Abstract</title><p>Background: Degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) in Parkinson's disease (PD) is responsible for motor and cognitive impairment. Replacing the dopaminergic cell population in the SNpc to restore normal dopamine levels is a potential therapeutic approach. However, improving neuronal integration still requires a reliable cell source for transplant...

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Literature Corpus work: 78d82bdd-1dcc-5c45-9469-94b28808f048
DOI: 10.21203/rs.3.rs-2085626/v1

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