Article

The DACH1 gene is frequently deleted in prostate cancer, restrains prostatic intraepithelial neoplasia, decreases DNA damage repair, and predicts therapy responses.

2023-01-10

Abstract excerpt

<title>Abstract</title> <p>Prostate cancer (PCa), the second leading cause of death in American men, includes distinct genetic subtypes with distinct therapeutic vulnerabilities. The <italic>DACH1 </italic>gene encodes a winged helix/Forkhead DNA-binding protein that competes for binding to FOXM1 sites. Herein, <italic>DACH1 </italic>gene deletion within the 13q21.31-q21.33 region occurs in up to 18% of human PCa...

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Literature Corpus work: 78d0a93b-10a9-5546-bab3-a927911a0ac0
DOI: 10.21203/rs.3.rs-2423179/v1

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