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RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer

18 Feb 2022

Abstract excerpt

Current targeted cancer therapies are largely guided by mutations of a single gene, which overlooks concurrent genomic alterations. Here, we show that RNASEH2B , RB1 , and BRCA2 , three closely located genes on chromosome 13q, are frequently deleted in prostate cancer individually or jointly. Loss of RNASEH2B confers cancer cells sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition due to impaired...

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PMID: 35179959
DOI: 10.1126/sciadv.abl9794

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