Article

RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer

2021-11-10

Abstract excerpt

Current targeted cancer therapies are largely guided by mutations of a single gene, which overlooks concurrent genomic alterations. Here, we show that RNASEH2B, RB1, and BRCA2, three closely located genes on chromosome 13q, are frequently deleted in prostate cancer individually or jointly. Loss of RNASEH2B confers cancer cells sensitivity to poly(ADP–ribose) polymerase (PARP) inhibition due to impaired ribonucleot...

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Literature Corpus work: 68994d19-c54a-598b-9dc2-4f00dab843ad
DOI: 10.1101/2021.11.08.467839

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