Article

Diazo-carboxyl click chemistry enables rapid and sensitive quantification of carboxylic acid metabolites

2023-05-13

Abstract excerpt

Carboxylic acids are central metabolites in bioenergetics, signal transduction and post-translation protein regulation. Unlike its genomic and transcriptomic counterparts, the quest for metabolomic profiling in trace amounts of biomedical samples is prohibitively challenging largely due to the lack of sensitive and robust quantification schemes for carboxylic acids. Based on diazo-carboxyl click chemistry, here we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 78c59e01-eef8-551e-913b-c832e2bd00a3
DOI: 10.1101/2023.05.11.540288

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Diazo-carboxyl click chemistry enables rapid and sensitive quantification of carboxylic acid metabolitesDOI 10.1101/2023.05.11.540288Read

An Optimized Method for LC-MS Based Quantification of Endogenous Organic Acids: Metabolic Perturbations in Pancreatic CancerSemantic proximity Read

A targeted metabolomic method to detect epigenetically relevant metabolitesSemantic proximity Read

Exploration of the Amino Acid Metabolic Signature in Anthracycline-induced Cardiotoxicity Using an Optimized Targeted Metabolomics Approach Based on UPLC-MS/MSSemantic proximity Read

Mass spectrometry in metabolome analysis.Semantic proximity Read

Reducing background ion burden in tributylamine ion-pairing LC-MS improves signal intensity and feature coverage in metabolomicsSemantic proximity Read

A multiomics approach to understanding pathology of Combined D,L-2- Hydroxyglutaric Aciduria and phenylbutyrate as potential treatmentSemantic proximity Read

Discovery of metabolites produced by reactions between central carbon metabolites and cysteine that mark inflammatory macrophagesSemantic proximity Read

Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis.Semantic proximity Read

Stable Isotope-Assisted Metabolomics for Deciphering Xenobiotic Metabolism in Mammalian Cell CultureSemantic proximity Read

Expanding and Decoding the Chemistry of Phospholipid Headgroup in EukaryotesSemantic proximity Read

A Synthesis-Based Reverse Metabolomics Approach for the Discovery of Chemical Structures from Humans and Animals.Semantic proximity Read

Early Differentiation Signatures in Human Induced Pluripotent Stem Cells Determined by Non-Targeted Metabolomics AnalysisSemantic proximity Read