Article

Stable Isotope-Assisted Metabolomics for Deciphering Xenobiotic Metabolism in Mammalian Cell Culture

2020-02-26

Abstract excerpt

We present a workflow based on stable isotope-assisted metabolomics and the bioinformatics tool MetExtract II for deciphering xenobiotic metabolites produced by human cells. Its potential was demonstrated by the investigation of the metabolism of deoxynivalenol (DON), an abundant food contaminatn, in a liver cracinoma cell line (HeoG2) and a model for colon carcinoma (HT29). Detected known metabolites included DON...

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Literature Corpus work: d6bd65af-5635-5114-a48f-eac9efac8609
DOI: 10.26434/chemrxiv.10293224.v2

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