Article

Exploration of the Amino Acid Metabolic Signature in Anthracycline-induced Cardiotoxicity Using an Optimized Targeted Metabolomics Approach Based on UPLC-MS/MS

2021-11-02

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Although anthracyclines improve the long-term survival rate of patients with cancer, severe and irreversible myocardial damage limits their clinical application. Amino acids (AAs) play critical roles in protein synthesis, energy generation, and metabolism, as well as maintenance of the normal structure of cardiomyocytes. Conversely, AA metabolism in cardiomyocyt...

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Literature Corpus work: 48e3206d-927b-56cf-b176-f9b5d07ff0c6
DOI: 10.21203/rs.3.rs-1018930/v1

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