Article

Reducing background ion burden in tributylamine ion-pairing LC-MS improves signal intensity and feature coverage in metabolomics

2026-06-25

Abstract excerpt

<h4>Background: </h4> chemical ions are a pervasive but often underappreciated limitation in LC-MS metabolomics, where they can suppress analyte signal, obscure endogenous metabolites, increase spectral complexity, and consume MS/MS acquisition events. Tributylamine (TBA) ion-pairing reversed-phase LC-MS provides stable retention and broad coverage of polar anionic metabolites, including central carbon intermediat...

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Literature Corpus work: 87ab1d7f-f835-5739-bf9e-5656f6435727
DOI: 10.64898/2026.06.24.734057

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