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Antiviral immunity and nucleic acid sensing in haematopoietic stem cell gene engineering

13 Jul 2020

Abstract excerpt

The low gene manipulation efficiency of human hematopoietic stem and progenitor cells (HSPC) remains a major hurdle for sustainable and broad clinical application of innovative therapies for a wide range of disorders. Given that all current and emerging gene transfer and editing technologies are bound to expose HSPC to exogenous nucleic acids and most often also to viral vectors, we reason that host antiviral...

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PMID: 32661282
DOI: 10.1038/s41434-020-0175-3

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