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Article

Saturation mutagenesis identifies activating and resistance-inducing FGFR kinase domain mutations.

Nature genetics - 1 Jan 2026

Tangermann Carla, Ghosh Avantika, Ziegler Martin, Facchinetti Francesco, Stappenbeck Jannis, Carus Sahin Yagmur Oyku, Riester Marisa, Viardot Luise Carmina, Zundel Tobias, Friboulet Luc, Hollebecque Antoine, Naveja José J, Wanninger Angela, Hess Maria Elena, Brummer Tilman, Boerries Melanie, Loges Sonja, Loriot Yohann, Illert Anna L, Diederichs Sven

Abstract excerpt

Variants of uncertain significance represent the biggest challenge for genomics-based precision oncology. Activated fibroblast growth factor receptors (FGFRs) frequently drive tumorigenesis by different genetic aberrations. However, it remains unknown which of the many point mutations affecting FGFR1, FGFR2, FGFR3 or FGFR4 in cancer are druggable, that is, activating signaling while not mediating FGFR inhibitor...

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Morpholines
Protein Domains
Pyridazines
Pyrroles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor, Fibroblast Growth Factor, Type 1

Receptor, Fibroblast Growth Factor, Type 2

Receptor, Fibroblast Growth Factor, Type 4

Receptors, Fibroblast Growth Factor

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Open in PubMed Open full text

Identifiers

PMID: 41361008
DOI: 10.1038/s41588-025-02431-8
PMCID: PMC12807871

Genes

FGFR1
FGFR2
FGFR3
FGFR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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