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Article

Multimodal LA-ICP-MS and nanoSIMS imaging enables copper mapping within photoreceptor megamitochondria in a zebrafish model of Menkes disease.

Metallomics : integrated biometal science - 1 Mar 2018

Ackerman Cheri M, Weber Peter K, Xiao Tong, Thai Bao, Kuo Tiffani J, Zhang Emily, Pett-Ridge Jennifer, Chang Christopher J

Abstract excerpt

Copper is essential for eukaryotic life, and animals must acquire this nutrient through the diet and distribute it to cells and organelles for proper function of biological targets. Indeed, mutations in the central copper exporter ATP7A contribute to a spectrum of diseases, including Menkes disease, with symptoms ranging from neurodegeneration to lax connective tissue. As such, a better understanding of the...

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Source

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Identifiers

PMID: 29507920
DOI: 10.1039/c7mt00349h
PMCID: PMC5864565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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