Atp7a deficiency induces axonal and myelin developmental defects in zebrafish via ferroptosis

Abstract excerpt

ATP7A genetic mutations lead to Menkes disease (MD), a hereditary neurodegenerative disorder develops significant metabolic abnormalities including copper deficiency and hypomyelination, and even death before 3 years old. However, the underlying mechanisms remain poorly understood. In this study, a dysfunction in axons as evidenced by the shortened axons, reduced branching in each axon, thinner spinal myelin...

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