Article

Phosphorylation-Dependent Activation of the XRCC1 Intrinsically Disordered Region: A Computational Structural Analysis

2026-04-21

Abstract excerpt

<title>Abstract</title> <p>The X-ray repair cross-complementing protein 1 (XRCC1) is a central scaffold protein involved in DNA single-strand break repair (SSBR), coordinating the assembly of multi-protein repair complexes. Its activity is regulated by post-translational modifications, particularly phosphorylation within intrinsically disordered regions (IDRs), although the structural consequences of these modifi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 788d7a93-6586-5a44-904d-151311e690c7
DOI: 10.21203/rs.3.rs-9455541/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation-Dependent Activation of the XRCC1 Intrinsically Disordered Region: A Computational Structural AnalysisDOI 10.21203/rs.3.rs-9455541/v1Read

Structural Perturbations and Destabilizing Mutations in RAD51C and RAD51D Reveal Mechanisms of Cancer RiskSemantic proximity Read

Site-directed mutagenesis analysis of the structural interaction of the single-strand-break repair protein, X-ray cross-complementing group 1, with DNA polymerase beta.Semantic proximity Read

Molecular insights into the activation of Mre11-Rad50 endonuclease activity by Sae2/CtIPSemantic proximity Read

Investigating the effects of the ARG258HIS mutation on RAD51C in inherited Fanconi Anemia and cancer disease.Semantic proximity Read

In silico study of effects of polymorphisms on biophysical chemical properties of oxidized N-terminal domain of X-ray cross-complementing group 1 protein.Semantic proximity Read

The Rev1 interacting region (RIR) motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair.Semantic proximity Read

Structural basis of Rad53 kinase activation by dimerization and activation segment exchange.Semantic proximity Read

Functional Assessment of Protein Variants in Structured Domains by Fluorescence Cross-Correlation SpectroscopySemantic proximity Read

Investigation of Structural Mechanisms Underlying p53 Dysfunction Caused by 148 Missense Mutations Using AlphaFold3 and Molecular Dynamics SimulationsSemantic proximity Read

Molecular dynamics simulations reveal R399Q mutation disrupts XRCC1-polβ interaction, potentially impairing DNA base excision repair pathway.Semantic proximity Read

Investigating the structural impacts of I64T and P311S mutations in APE1-DNA complex: a molecular dynamics approach.Semantic proximity Read

Variant of uncertain significance Arg866Cys enhances disorderedness of h-BRCA1 (759-1064) region.Semantic proximity Read