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Sulfonic DJ-1 (Cys<sup>106</sup>-SO<sub>3</sub>H) Binds to and Colocalizes with the Intracellular Accumulation of Amyloid-Beta 42 (Aβ42) in Familial Alzheimer’s Disease PSEN1 E280A Cerebral Organoids Derived from Induced Pluripotent Stem Cells

2025-11-21

Abstract excerpt

The intracellular accumulation of amyloid beta 42 (iAβ42) has been proposed as an early pathological indicator of familial Alzheimer’s disease (FAD). DJ-1 is a multifunctional protein sensitive to oxidative stress (OS) that has been associated with neurodegeneration; however, its role in iAβ42 pathology is unclear. In this study, we examined whether oxidized (sulfonic) DJ-1 (Cys106-SO₃) drives iAβ42 accumulation u...

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Literature Corpus work
2fa15ac5-07af-58fc-b59f-5df22d9cee4f
DOI
10.20944/preprints202511.1634.v1
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Sulfonic DJ-1 (Cys<sup>106</sup>-SO<sub>3</sub>H) Binds to and Colocalizes with the Intracellular Accumulation of Amyloid-Beta 42 (Aβ42) in Familial Alzheimer’s Disease PSEN1 E280A Cerebral Organoids Derived from Induced Pluripotent Stem CellsDOI 10.20944/preprints202511.1634.v1
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