Article

A motif-vocabulary model of CAR T-cell intracellular domains identifies determinants of immunophenotype differentiation

2026-02-05

Abstract excerpt

Chimeric antigen receptor (CAR) T-cell efficacy depends critically on the costimulatory domain, which shapes downstream signaling and the immunophenotype of manufactured products. Despite mechanistic evidence that immune receptors function as motif-based signaling scaffolds, CAR engineering has focused on a narrow set of costimulatory domains—principally CD28 and 4-1BB—leaving much of the available signaling desig...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 788550a1-bbd3-50eb-a9df-84a376d7c95b
DOI: 10.64898/2026.02.01.700582

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A motif-vocabulary model of CAR T-cell intracellular domains identifies determinants of immunophenotype differentiationDOI 10.64898/2026.02.01.700582Read

Decoding CAR T cell phenotype using combinatorial signaling motif libraries and machine learning.Semantic proximity Read

Exploring the rules of chimeric antigen receptor phenotypic output using combinatorial signaling motif libraries and machine learningSemantic proximity Read

Dissecting the role of CAR signaling architectures on T cell activation and persistence using pooled screens and single-cell sequencingSemantic proximity Read

Selecting costimulatory domains for chimeric antigen receptors: functional and clinical considerationsSemantic proximity Read

CARPOOL: A library-based platform to rapidly identify next generation chimeric antigen receptorsSemantic proximity Read

Library-based single-cell analysis of CAR signaling reveals drivers of <i>in vivo</i> persistenceSemantic proximity Read

Engineering next-generation chimeric antigen receptor-T cells: recent breakthroughs and remaining challenges in design and screening of novel chimeric antigen receptor variantsSemantic proximity Read

Rational Tuning of CAR Tonic Signaling Yields Superior T-Cell Therapy for CancerSemantic proximity Read

Integrating binding affinity and tonic signaling enables a rational CAR design for augmented T cell functionSemantic proximity Read

CD28 Costimulatory Domain-Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function.Semantic proximity Read

A quantitative intracellular peptide binding assay reveals recognition determinants and context dependence of short linear motifsSemantic proximity Read

Membrane positioning across antigen-induced synaptic contacts tunes CAR-T cell signaling and effector responsesSemantic proximity Read