Back to search

Article

“Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression”

2023-03-02

Abstract excerpt

The sparse vascularity of Pancreatic Ductal Adenocarcinoma (PDAC) presents a mystery: what prevents this aggressive malignancy from undergoing neoangiogenesis to counteract hypoxia and better support growth? An incidental finding from prior work on paracrine communication between malignant PDAC cells and fibroblasts revealed that inhibition of the Hedgehog (HH) pathway partially relieved angiosuppression, increasi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
787c2148-b14c-5e3d-ae2d-d83d0d2dc2c9
DOI
10.1101/2023.03.02.529724
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
“Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression”DOI 10.1101/2023.03.02.529724
Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer AngiosuppressionSemantic proximity
Assessment of the stromal contribution to Sonic Hedgehog‐dependent pancreatic adenocarcinomaSemantic proximity
Angiogenic gene signature in human pancreatic cancer correlates with TGF-beta and inflammatory transcriptomesSemantic proximity
Cancer Associated Fibroblast (CAF) regulation of PDAC parenchymal (CPC) and CSC phenotypes is modulated by ECM composition.Semantic proximity
Characterization of Tumor-Associated Endothelial Cells and the Development of a Prognostic Model in Pancreatic Ductal AdenocarcinomaSemantic proximity
Cancer Associated Fibroblast (CAF) Regulation of PDAC Parenchymal (CPC) and CSC Phenotypes Is Modulated by ECM CompositionSemantic proximity
Extravascular coagulation stabilizes pro-fibrotic stromal states via tumor-intrinsic PAR1 signaling in pancreatic ductal adenocarcinomaSemantic proximity
Sonic hedgehog inhibitor suppresses carcinoma associated fibroblasts to prime Gemcitabine/Nab-Paclitaxel and anti-CTLA4 immunotherapy as sequential first-line combination therapy in a Phase 1b/2 study in PDAC: NUMANTIA trialSemantic proximity
Hedgehog Signaling: Networking to Nurture a Promalignant Tumor MicroenvironmentSemantic proximity
Hhip regulates tumor-stroma-mediated upregulation of tumor angiogenesis.Semantic proximity
A model for angiogenesis suppression via SERPINF1 in the surrounding pro-acinar microenvironment during human fetal pancreas developmentSemantic proximity
Metformin suppresses tumor angiogenesis and enhances the chemosensitivity of gemcitabine in a genetically engineered mouse model of pancreatic cancer.Semantic proximity
Select a neighboring publication to make it the new centre.