Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression

14 Nov 2023

Abstract excerpt

The sparse vascularity of pancreatic ductal adenocarcinoma (PDAC) presents a mystery: What prevents this aggressive malignancy from undergoing neoangiogenesis to counteract hypoxia and better support growth? An incidental finding from prior work on paracrine communication between malignant PDAC cells and fibroblasts revealed that inhibition of the Hedgehog (HH) pathway partially relieved angiosuppression,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Genetic and Kidney Cyst Diseases
Share to Hedgehog Signaling Pathway Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37966260
DOI: 10.1158/2159-8290.cd-23-0240

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer AngiosuppressionPMID 37966260Read ↗

“Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression”Semantic proximity Read ↗

Dosage-Dependent Regulation of Pancreatic Cancer Growth and Angiogenesis by Hedgehog SignalingSemantic proximity Read ↗

Platelet-derived growth factor-BB controls epithelial tumor phenotype by differential growth factor regulation in stromal cells.Semantic proximity Read ↗

Assessment of the stromal contribution to Sonic Hedgehog‐dependent pancreatic adenocarcinomaSemantic proximity Read ↗

Angiogenic gene signature in human pancreatic cancer correlates with TGF-beta and inflammatory transcriptomesSemantic proximity Read ↗

Stromal biology of pancreatic cancerSemantic proximity Read ↗

Sonic hedgehog inhibitor suppresses carcinoma associated fibroblasts to prime Gemcitabine/Nab-Paclitaxel and anti-CTLA4 immunotherapy as sequential first-line combination therapy in a Phase 1b/2 study in PDAC: NUMANTIA trialSemantic proximity Read ↗

Metastatic phenotype and immunosuppressive tumour microenvironment in pancreatic ductal adenocarcinoma: Key role of the urokinase plasminogen activator (PLAU).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.