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Increased intestinal permeability in an orally-reactive peanut allergy model identifies Angiopoietin like-4 as a biomarker

2021-07-15

Abstract excerpt

Peanut allergy reaction severity correlates with increased intestinal epithelial cell (IEC) barrier permeability. CC027/GeniUnc mice develop peanut allergy by intragastric administration of peanut proteins without adjuvant. We report that peanut-allergic CC027/GeniUnc mice showed increased IEC barrier permeability and systemic peanut allergen Ara h 2 after challenge. Jejunal epithelial cell transcriptomics showed...

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Identifiers and source

Literature Corpus work
78773676-bebc-51a5-b939-39ea888e4eb2
DOI
10.1101/2021.07.14.452416
Open publication

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Increased intestinal permeability in an orally-reactive peanut allergy model identifies Angiopoietin like-4 as a biomarkerDOI 10.1101/2021.07.14.452416
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