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Article

Exploratory imaging-genetics associations between habenula connectivity and symptom severity in major depressive disorder.

Journal of affective disorders - 15 Jul 2026

Kim Mansu, Jung Ju-Yeon, Kang Chang-Ki, Kang Seung-Gul

Abstract excerpt

OBJECTIVE: The habenula is implicated in mood regulation and sleep-wake processes and has been increasingly studied in major depressive disorder (MDD). This exploratory imaging-genetics study examined the potential associations between candidate gene polymorphisms, habenula-centered brain connectivity, and clinical symptom severity in patients with MDD. METHODS: Ten candidate genes related to mood and circadian...

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Identifiers

PMID: 41825747
DOI: 10.1016/j.jad.2026.121610

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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