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Article

Chain-length determination mechanism of isoprenyl diphosphate synthases and implications for molecular evolution.

Trends in biochemical sciences - 1 Nov 1999

Wang K, Ohnuma S

Abstract excerpt

In the synthesis of isoprenoids, isoprenyl diphosphate synthases catalyze the consecutive condensation of isopentenyl diphosphate with allylic diphosphates to produce a variety of prenyl diphosphates with well-defined chain lengths. Site-directed mutagenesis in conjunction with X-ray crystallographic studies have identified specific amino acid residues responsible for chain-length determination. Simple...

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Identifiers

PMID: 10542413
DOI: 10.1016/s0968-0004(99)01464-4

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Source receipt: pubmed, retrieved 7 Sept 2026.

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