Article
Chain-length determination mechanism of isoprenyl diphosphate synthases and implications for molecular evolution.
Trends in biochemical sciences - 1 Nov 1999
Wang K, Ohnuma S
Abstract excerpt
In the synthesis of isoprenoids, isoprenyl diphosphate synthases catalyze the consecutive condensation of isopentenyl diphosphate with allylic diphosphates to produce a variety of prenyl diphosphates with well-defined chain lengths. Site-directed mutagenesis in conjunction with X-ray crystallographic studies have identified specific amino acid residues responsible for chain-length determination. Simple...
Topics
- Alkyl and Aryl Transferases
- Amino Acid Sequence
- Animals
- Conserved Sequence
- Evolution, Molecular
- Farnesyltranstransferase
- Genetic Variation
- Humans
- Molecular Weight
- Phylogeny
- Protein Conformation