Article

Coptisine inhibits the proliferation of hepatocellular carcinoma by promoting ubiquitination of IGF2BP1

2022-07-14

Abstract excerpt

<h4>Background: </h4> Hepatocellular carcinoma (HCC) is a leading cause of death in humans. Clinical investigations have reported that insulin-like growth factor 2 (IGF2) mRNA binding protein 1 (IGF2BP1) is overexpressed in HCC, promoting oncogene activation, and is associated with cancer progression and poor prognosis. Previous research from our laboratory found that coptisine (COP) could inhibit the proliferatio...

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Literature Corpus work: 78688847-ce8d-5f00-a763-a66ce4f3d54f
DOI: 10.21203/rs.3.rs-1821713/v1

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