COPB2 promotes hepatocellular carcinoma progression through regulation of YAP1 nuclear translocation

Abstract excerpt

The Hippo pathway has been shown to be upregulated in many cancer patients. Yes-associated protein 1 (YAP1), an oncogene and core factor of the Hippo pathway, plays a key role in tumorigenesis and progression. Although YAP1 is a vital oncogene in HCC progression, its nuclear localization prevents its consideration as a potential therapeutic target. Recently, studies have reported that COPB2 also plays a critical r...

Topics

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• Gene Expression Regulation, Neoplastic
• Genes, Tumor Suppressor
• Hippo pathway signaling and YAP/TAZ
• Molecular Targeted Therapy
• Mutation
• Neoplasms
• Pancreatic function and diabetes
• Ubiquitin-Protein Ligases

Identifiers and source

Literature Corpus work

c36afefe-255b-5324-b118-60289beba192

DOI

10.21203/rs.3.rs-4117273/v1