Article

Inhibition of Importin 7-mediated IPO7/c-Myc/IPO7 positive feedback loop suppresses DNA damage repair and improves sorafenib sensitivity in hepatocellular carcinoma

2023-11-11

Abstract excerpt

<h4>Background: </h4> ： Hepatocellular carcinoma (HCC) is a common malignancy worldwide with an increasing incidence. Sorafenib is currently the first-line treatment for HCC. However, drug resistance resulting from patients' insensitivity to the medication remains a major cause of high mortality. The specific mechanisms underlying sorafenib resistance in HCC have not yet been fully elucidated. <h4>Methods: </h4>：...

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Literature Corpus work: 04b5c771-5db6-5843-9834-a06ff3245fc3
DOI: 10.21203/rs.3.rs-3578022/v1

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