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Article

Definition of ubiquitination modulator COP1 as a novel therapeutic target in human hepatocellular carcinoma.

Cancer research - 1 Nov 2010

Lee Yun-Han, Andersen Jesper B, Song Ho-Taek, Judge Adam D, Seo Daekwan, Ishikawa Tsuyoshi, Marquardt Jens U, Kitade Mitsuteru, Durkin Marian E, Raggi Chiara, Woo Hyun Goo, Conner Elizabeth A, Avital Itzhak, Maclachlan Ian, Factor Valentina M, Thorgeirsson Snorri S

Abstract excerpt

The development of targeted therapeutics for hepatocellular carcinoma (HCC) remains a major challenge. The ubiquitination modulator COP1 regulates p53 activity by ubiquitination and it is frequently overexpressed in human HCC. In this study, we tested the hypothesis that COP1 blockade by short interfering RNA (siRNA)-mediated inhibition could affect the course of HCC progression. The COP1 isoform COP1-1 was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20959491
DOI: 10.1158/0008-5472.CAN-10-0749
PMCID: PMC2970744

Genes

COP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Definition of ubiquitination modulator COP1 as a novel therapeutic target in human hepatocellular carcinoma.PMID 20959491Read ↗

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