Article

Multiomics approach identifies SERPINB1 as candidate progression biomarker for Spinocerebellar Ataxia type 2

2025-04-20

Abstract excerpt

<h4>Background</h4> Spinocerebellar ataxia type 2 (SCA2) is a polyglutamine disorder, and variants in its disease protein Ataxin-2 act as modifiers in the progression of Amyotrophic Lateral Sclerosis. There are no reliable molecular progression biomarkers for SCA2. <h4>Objectives</h4> The aim of this study was to define novel molecular progression biomarker candidates for SCA2. <h4>Methods</h4> Using cerebellar...

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Literature Corpus work: 785517ee-0d2a-5953-9c9e-170333619316
DOI: 10.1101/2025.04.18.649103

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