Article

Stabilized gp120-specific CD4 for next-generation HIV-1 inhibitors

2026-03-27

Abstract excerpt

HIV-1 Env’s gp120 subunit uses the T-cell coreceptor CD4 to enter host cells in a manner that prevents the evolution of host resistance by sharing the binding epitope with the footprint of CD4’s natural ligands, class II MHC proteins 1,2 . Consequently, CD4-containing biologics, such as CD4-Ig 3,4 and derivatives 5–9 , benefit from this conserved relationship and are promising broad-acting anti-HIV-1 agents tha...

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Literature Corpus work: 784655e4-bf23-5346-a9b6-7b93672ed0e7
DOI: 10.64898/2026.03.24.713825

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