Article

Studies of glucocorticord resistance in chronic lymphocytic leukaemia

2012-01-01

Abstract excerpt

Glucocorticoids represent an important component of modern treatment regimens for patients with fludarabine-refractory or TP53-defective chronic lymphocytic leukaemia. However, not all patients respond to GC therapy. This in-vitro study / investigated-the molecular mechanisms responsible for GC resistance in a cohort / / of 46 primary CLL samples. As expected, dexamethasone-induced killing was more pronounced in c...

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Literature Corpus work: 783eab91-3ac9-5fbf-b7d6-5aa848868765
DOI: 10.17638/03062835

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