Article
Glucocorticoid-induced apoptosis and glucocorticoid resistance in acute lymphoblastic leukemia.
The Journal of steroid biochemistry and molecular biology - 1 Feb 2005
Ploner Christian, Schmidt Stefan, Presul Elisabeth, Renner Kathrin, Schröcksnadel Kathrin, Rainer Johannes, Riml Stefan, Kofler Reinhard
Abstract excerpt
Glucocorticoids (GC) induce cell cycle arrest and apoptosis in lymphoid cells, and therefore constitute a central component in the treatment of lymphoid malignancies, particularly childhood acute lymphoblastic leukemia (ALL). In spite of its clinical significance and considerable efforts in many laboratories, however, the molecular basis of GC-induced apoptosis and the clinically important resistance phenomenon...
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