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Article

Differential gene expression profile associated to apoptosis induced by dexamethasone in CLL cells according to IGHV/ZAP-70 status.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2012

Baptista Maria Joao, Muntañola Ana, Calpe Eva, Abrisqueta Pau, Salamero Olga, Fernández Eva, Codony Carles, Giné Eva, Kalko Susana G, Crespo Marta, Bosch Francesc

Abstract excerpt

PURPOSE: Glucocorticoids are part of the therapeutic armamentarium of chronic lymphocytic leukemia (CLL) where it has been suggested that cells with unmutated IGHV genes exhibit higher sensitivity. The mechanisms by which glucocorticoids are active in CLL are not well elucidated. We aimed to asce...

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Share to Apoptosis Regulatory Proteins
Share to Bcl-2-Like Protein 11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dexamethasone

Share to Gene Expression Regulation, Leukemic

Share to Genes, Immunoglobulin Heavy Chain

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Tacrolimus Binding Proteins

Share to ZAP-70 Protein-Tyrosine Kinase

Source

Identifiers

PMID: 22966019
DOI: 10.1158/1078-0432.CCR-11-2771

Genes

FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22966019-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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