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Article

Resistance to glucocorticoid-induced apoptosis in lymphoblastic leukemia

1 Jul 2003

Abstract excerpt

Glucocorticoid (GC) resistance is a phenomenon of major significance in a number of clinical situations, including the therapy of lymphoid malignancies. Resistance may concern all, or just selected, GC effects, it may be absolute or just reflect a state of reduced sensitivity and, clinically relevant, be reversible or irreversible. Numerous molecular mechanisms can be envisaged acting either 'upstream' in the...

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PMID: 12844332
DOI: 10.1677/joe.0.1780019

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