Applying CRISPR-based genetic screens to identify drivers of tumor-cell sensitivity towards NK-cell attack

Abstract excerpt

<h4>ABSTRACT</h4> Natural killer (NK) cells distinguish cancer cells from healthy cells using an array of germline-encoded receptors that interact with ligands expressed on target cells. A balance of inhibitory and activating signals transduced by these receptors regulate NK cell function to provide anti-tumor immunity while maintaining self-tolerance. However, knowledge of the spectrum of factors regulating NK-c...

Topics

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• CAR-T cell therapy research
• CRISPR and Genetic Engineering
• Immune Cell Function and Interaction
• Protein Degradation and Inhibitors
• T-cell and B-cell Immunology
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

047d86bf-0879-55ec-96c5-3e25dbddfb62

DOI

10.1101/531962