Multi-omic profiling of tyrosine kinase inhibitor-resistant K562 cells suggests metabolic reprogramming to promote cell survival

Abstract excerpt

Resistance to chemotherapy can occur through a wide variety of mechanisms. Resistance to tyrosine kinase inhibitors (TKIs) often arises from kinase mutations-however, “off-target” resistance occurs but is poorly understood. Previously, we established cell line resistance models for three TKIs used in chronic myeloid leukemia treatment, and found that resistance was not attributed entirely to failure of kinase inhi...

Topics

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• Acute Myeloid Leukemia Research
• Cancer, Hypoxia, and Metabolism
• Drug Resistance, Neoplasm
• Histone Deacetylase Inhibitors Research
• Melanoma
• Mitochondrial Function and Pathology
• Pancreatic function and diabetes
• Protein Kinase Inhibitors

Identifiers and source

Literature Corpus work

783de4b3-e79f-5bcf-ba76-fa6b4a648112

DOI

10.1101/308528