Article
Severe peri-ictal respiratory dysfunction is common in Dravet syndrome.
The Journal of clinical investigation - 1 Mar 2018
Kim YuJaung, Bravo Eduardo, Thirnbeck Caitlin K, Smith-Mellecker Lori A, Kim Se Hee, Gehlbach Brian K, Laux Linda C, Zhou Xiuqiong, Nordli Douglas R, Richerson George B
Abstract excerpt
Dravet syndrome (DS) is a severe childhood-onset epilepsy commonly due to mutations of the sodium channel gene SCN1A. Patients with DS have a high risk of sudden unexplained death in epilepsy (SUDEP), widely believed to be due to cardiac mechanisms. Here we show that patients with DS commonly have peri-ictal respiratory dysfunction. One patient had severe and prolonged postictal hypoventilation during video EEG...
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