Article

Recent evolution of the mutation rate and spectrum in Europeans

2014-10-14

Abstract excerpt

As humans dispersed out of Africa, they adapted to new environmental challenges including changes in exposure to mutagenic solar radiation. Humans in temperate latitudes have acquired light skin that is relatively transparent to ultraviolet light, and some evidence suggests that their DNA damage response pathways have also experienced local adaptation. This raises the possibility that different populations have ex...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 78314e5e-f54d-5161-b5e6-792bc67bf30f
DOI: 10.1101/010314

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Recent evolution of the mutation rate and spectrum in EuropeansDOI 10.1101/010314Read

Evidence for recent, population-specific evolution of the human mutation rate.Semantic proximity Read

The origins, determinants, and consequences of human mutations.Semantic proximity Read

A comprehensive catalogue of somatic mutations from a human cancer genome.Semantic proximity Read

Signatures of Mutational Processes in Human DNA EvolutionSemantic proximity Read

Limited role of generation time changes in driving the evolution of mutation spectrum in humansSemantic proximity Read

Mutational epidemiology: achievements and expectations on enhancing our understanding of the causes of cancer.Semantic proximity Read

Toward a geographical history of the predominant and secondary mutations in Europe.Semantic proximity Read

Differences in the rare variant spectrum among human populations.Semantic proximity Read

Differences in the rare variant spectrum among human populationsSemantic proximity Read

Limited role of generation time changes in driving the evolution of the mutation spectrum in humans.Semantic proximity Read

Effects of psoriasis and psoralen exposure on the somatic mutation landscape of the skinSemantic proximity Read

The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts.Semantic proximity Read