Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence for recent, population-specific evolution of the human mutation rate.

Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 2015

Harris Kelley

Abstract excerpt

As humans dispersed out of Africa they adapted to new environmental challenges, including changes in exposure to mutagenic solar radiation. Humans in temperate latitudes have acquired light skin that is relatively transparent to UV light, and some evidence suggests that their DNA damage response pathways have also experienced local adaptation. This raises the possibility that different populations have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Evolution
Share to Computational Biology
Share to Europe

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Genetics, Population

Share to Mutation

Share to Mutation Rate

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 25733855
DOI: 10.1073/pnas.1418652112
PMCID: PMC4371947

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for recent, population-specific evolution of the human mutation rate.PMID 25733855Read ↗

Recent evolution of the mutation rate and spectrum in EuropeansSemantic proximity Read ↗

Limited role of generation time changes in driving the evolution of mutation spectrum in humansSemantic proximity Read ↗

Signatures of Mutational Processes in Human DNA EvolutionSemantic proximity Read ↗

Limited role of generation time changes in driving the evolution of the mutation spectrum in humans.Semantic proximity Read ↗

Differences in the rare variant spectrum among human populations.Semantic proximity Read ↗

Differences in the rare variant spectrum among human populationsSemantic proximity Read ↗

Rapid evolution of the human mutation spectrumSemantic proximity Read ↗

Mutational epidemiology: achievements and expectations on enhancing our understanding of the causes of cancer.Semantic proximity Read ↗

The origin of human mutation in light of genomic data.Semantic proximity Read ↗

Protein molecular function influences mutation rates in human genetic diseases with allelic heterogeneity.Semantic proximity Read ↗

A mutation rate model at the basepair resolution identifies the mutagenic effect of polymerase III transcription.Semantic proximity Read ↗

The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.