Article

Limited role of generation time changes in driving the evolution of mutation spectrum in humans

2022-06-18

Abstract excerpt

Recent studies have suggested that the human germline mutation rate and spectrum evolve rapidly. Variation in generation time has been linked to these changes, though its contribution remains unclear. We develop a framework to characterize temporal changes in polymorphisms within and between populations, while controlling for the effects of natural selection and biased gene conversion. Application to the 1000 Geno...

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Literature Corpus work: 4c9426c6-4153-5bda-89c7-160fd721b070
DOI: 10.1101/2022.06.17.496622

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