Article

Development and validation of HIV SMRTcap for the characterization of HIV-1 reservoirs across tissues and subtypes

2025-05-07

Abstract excerpt

<h4>ABSTRACT</h4> Human Immunodeficiency Virus type 1 (HIV-1) is responsible for the global HIV/AIDS epidemic and the establishment of an integrated HIV-1 reservoir remains the primary obstacle to cure. Upon therapy interruption, reactivation of the persistent HIV-1 reservoir propagates viral rebound and mediates continued immunological decline. While furthering understanding of the HIV-1 reservoir is essential f...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 05da0bd0-3b15-54a8-bec0-efd06d4ec890
DOI: 10.1101/2025.05.01.651657

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Development and validation of HIV SMRTcap for the characterization of HIV-1 reservoirs across tissues and subtypesDOI 10.1101/2025.05.01.651657Read

Near full-length HIV sequencing in multiple tissues collected postmortem reveals shared clonal expansions across distinct reservoirs during ARTSemantic proximity Read

HIV-PULSE: a long-read sequencing assay for high-throughput near full-length HIV-1 proviral genome characterizationSemantic proximity Read

Chemistry and Bioinformatics Considerations in Using Next-Generation Sequencing Technologies to Inferring HIV Proviral DNA Genome-IntactnessSemantic proximity Read

The latent HIV reservoir: current advances in genetic sequencing approachesSemantic proximity Read

New Frontiers in Measuring and Characterizing the HIV ReservoirSemantic proximity Read

HIV-1 virome profiling using HIV-PULSE to guide therapeutic and curative interventions.Semantic proximity Read

Barcoded HIV-1 reveals viral persistence driven by clonal proliferation and distinct epigenetic patterns.Semantic proximity Read

Identification of Genetically Intact HIV-1 Proviruses in Specific CD4+ T Cells from Effectively Treated ParticipantsSemantic proximity Read

Advancements in single-cell techniques for examining the HIV reservoir: pathways to a cureSemantic proximity Read

HIV proviral genetic diversity, compartmentalization and inferred dynamics in lung and blood during long-term suppressive antiretroviral therapy.Semantic proximity Read

Assessment of HIV-1 integration in tissues and subsets across infection stagesSemantic proximity Read

Integrative Assessment of Total and Intact HIV-1 Reservoir by a 5-Region Multiplexed Rainbow DNA Digital PCR AssaySemantic proximity Read