Article

Protein Abundance Inference via Expectation Maximization in Fluorosequencing

2025-07-14

Abstract excerpt

1 Fluorosequencing produces millions of single-peptide reads, yet a principled strategy for converting these data into quantitative protein abundances has been lacking. We introduce a probabilistic framework that adapts expectation maximization to the fluorosequencing measurement process, estimating relative protein abundances with peptide inference results delivered by previously developed peptide-classification...

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Literature Corpus work: 780b5cb6-c916-5958-9c01-f9142aa969e8
DOI: 10.1101/2025.07.10.664057

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