Article

Focus on the spectra that matter by clustering of quantification data in shotgun proteomics

2018-12-06

Abstract excerpt

In shotgun proteomics, the information extractable from label-free quantification experiments is typically limited by the identification rate and the noise level in the quantitative data. This generally causes a low sensitivity in differential expression analysis on protein level. Here, we propose a quantification-first approach for peptides that reverses the classical identification-first workflow. This prevents...

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Literature Corpus work: a7e3dad2-93eb-57f3-ab96-c33f0980900d
DOI: 10.1101/488015

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