Optimization and Characterization of the Antimalarial Activity of N -Aryl Acetamides that are Susceptible to Mutations in ROM8 and CSC1

Abstract excerpt

Abstract New antimalarials are needed due to the threat of emerging resistance against existing antimalarial therapies. A phenotypic screen uncovered the N-aryl acetamide class that inhibits the development of P. falciparum asexual ring-stage parasites. The structure–activity relationship of this class was investigated, and key modifications were introduced that produced WEHI-326 with potent antimalarial...

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