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Article

FOXD3 Modulates Migration through Direct Transcriptional Repression of TWIST1 in Melanoma

25 Jul 2014

Abstract excerpt

UNLABELLED: The neural crest is a multipotent, highly migratory cell population that gives rise to diverse cell types, including melanocytes. Factors regulating the development of the neural crest and emigration of its cells are likely to influence melanoma metastasis. The transcription factor FOXD3 plays an essential role in premigratory neural crest development and has been implicated in melanoma cell dormancy...

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PMID: 25061102
DOI: 10.1158/1541-7786.mcr-14-0170

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