Article
Integrated genomic characterization of adrenocortical carcinoma.
Nature genetics - 1 Jun 2014
Assié Guillaume, Letouzé Eric, Fassnacht Martin, Jouinot Anne, Luscap Windy, Barreau Olivia, Omeiri Hanin, Rodriguez Stéphanie, Perlemoine Karine, René-Corail Fernande, Elarouci Nabila, Sbiera Silviu, Kroiss Matthias, Allolio Bruno, Waldmann Jens, Quinkler Marcus, Mannelli Massimo, Mantero Franco, Papathomas Thomas, De Krijger Ronald, Tabarin Antoine, Kerlan Véronique, Baudin Eric, Tissier Frédérique, Dousset Bertrand, Groussin Lionel, Amar Laurence, Clauser Eric, Bertagna Xavier, Ragazzon Bruno, Beuschlein Felix, Libé Rossella, de Reyniès Aurélien, Bertherat Jérôme
Abstract excerpt
Adrenocortical carcinomas (ACCs) are aggressive cancers originating in the cortex of the adrenal gland. Despite overall poor prognosis, ACC outcome is heterogeneous. We performed exome sequencing and SNP array analysis of 45 ACCs and identified recurrent alterations in known driver genes (CTNNB1, TP53, CDKN2A, RB1 and MEN1) and in genes not previously reported in ACC (ZNRF3, DAXX, TERT and MED12), which we...
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