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Article

Immune regulation by glucocorticoids can be linked to cell type–dependent transcriptional responses

23 Jan 2019

Abstract excerpt

Glucocorticoids remain the most widely used immunosuppressive and anti-inflammatory drugs, yet substantial gaps exist in our understanding of glucocorticoid-mediated immunoregulation. To address this, we generated a pathway-level map of the transcriptional effects of glucocorticoids on nine primary human cell types. This analysis revealed that the response to glucocorticoids is highly cell type dependent, in...

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PMID: 30674564
DOI: 10.1084/jem.20180595

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