Article

Reconstruction of microbial haplotypes by integration of statistical and physical linkage in scaffolding

2020-03-30

Abstract excerpt

<h4>ABSTRACT</h4> DNA sequencing technologies provide unprecedented opportunities to analyze within-host evolution of microorganism populations. Often, within-host populations are analyzed via pooled sequencing of the population, which contains multiple individuals or ‘haplotypes’. However, current next-generation sequencing instruments, in conjunction with single-molecule barcoded linked-reads, cannot distinguis...

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Literature Corpus work: 77cf930b-4fa7-57f3-b919-aca440dec5c6
DOI: 10.1101/2020.03.29.014704

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