Article

Cytoplasmic tail of the putative polycystin channel Pkd2 regulates its clustering in the fission yeast eisosomes

2022-08-11

Abstract excerpt

Polycystins are a family of conserved ion channels, mutations of which lead to human genetic disorder Autosomal Dominant Polycystic Kidney Disease. The unicellular model organism fission yeast Schizosacchromyces pombe possesses single essential polycystin Pkd2 that localizes to the plasma membrane and is required for cell proliferation. Here, we carried out a functional analysis of Pkd2 based on its Alphafold pre...

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Literature Corpus work: 77a66ea3-deb8-54f6-8d40-0a01ba55cf67
DOI: 10.1101/2022.08.11.503631

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